CLINICAL EVIDENCE

Building Evidence for Longitudinal Cardiac Imaging

Sonologi is evaluating its wearable ultrasound and AI platform in clinical environments to understand its ability to capture and interpret cardiac information over time.

The company's clinical development strategy begins with high-acuity cardiac settings, where changes in patient condition can occur between conventional examinations.

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EVIDENCE HIGHLIGHTS

EARLY CLINICAL FEASIBILITY

10+ ICU Patients

Early Testing in High-Acuity Care

Sonologi's wearable ultrasound technology has undergone early testing in more than 10 intensive care unit patients.

This work has been used to evaluate the feasibility of wearable cardiac imaging in a real clinical environment and to inform continued development of the device, imaging workflow and analysis platform.

Preliminary clinical and technical evaluation

AI MODEL DEVELOPMENT

5.6 mmHg

Reported Error in a Small Held-Out Cohort

In a held-out cohort of 47 patients, the model reported an error of 5.6 mmHg for the evaluated cardiac pressure-estimation task.

The cohort was small and consisted primarily of patients with HFrEF, defined in this study context as LVEF of 40% or below.

Requires larger, more diverse and prospective validation

VALIDATION QUESTIONS

What Sonologi Is Evaluating

Continuous cardiac ultrasound must demonstrate more than image capture alone. Sonologi is evaluating the technical, analytical and clinical questions required to support longitudinal imaging.

01

Wearability

Can cardiac ultrasound data be captured through a wearable system in real clinical settings?

02

Imaging Continuity

Can the platform maintain useful cardiac imaging information over an extended observation period?

03

AI Interpretation

Can AI identify measurements, patterns and trends within longitudinal ultrasound data?

04

Clinical Utility

Can longitudinal imaging provide clinicians with information that is not available from isolated examinations alone?

EARLY TESTING IN ICU PATIENTS

Evaluating Wearable Cardiac Imaging in a Real Clinical Environment

Sonologi's wearable ultrasound technology has undergone early testing in more than 10 intensive care unit patients.

This work has been used to evaluate the feasibility of wearable cardiac imaging in a real clinical environment and to inform the continued development of the device, imaging workflow and analysis platform.

These findings represent early-stage clinical and technical evaluation. They should not be interpreted as evidence of commercial availability, regulatory clearance or definitive clinical efficacy.

Setting

Intensive Care Unit

Evaluation Focus

Wearability, imaging workflow and acquisition feasibility

Evidence Stage

Early clinical and technical evaluation

AI MODEL DEVELOPMENT

Exploring Cardiac Pressure Estimation from Ultrasound Imaging

5.6 mmHg reported error

Small held-out cohort, n=47

Early model development has explored whether ultrasound imaging information can be used to estimate clinically relevant cardiac measurements.

In a small held-out cohort of 47 patients, the model reported an error of 5.6 mmHg for the evaluated pressure-estimation task.

Important Context

The reported cohort was limited primarily to patients with heart failure with reduced ejection fraction, or HFrEF, defined in the study context as LVEF of 40% or below.

The result was obtained from a small held-out research cohort and requires validation in larger, more diverse and prospective patient populations.

INITIAL CLINICAL SETTINGS

Beginning Where Changes Can Be Difficult to Observe

Sonologi's early clinical strategy focuses on settings where patients face elevated risk and where intermittent assessments may leave important changes unobserved.

01

High-Acuity Care

Continuous or repeated imaging may provide additional visibility into cardiac changes in closely monitored patients.

02

Heart Failure Management

Longitudinal imaging may help clinicians understand how cardiac function changes during treatment, recovery and disease progression.

03

Post-Discharge Monitoring

The period after hospital discharge is a vulnerable time for many heart failure patients. Sonologi is exploring how continuous imaging could extend cardiac visibility beyond the hospital.

CLINICAL DEVELOPMENT PATH

A Staged Path from Platform Development to Clinical Use

Sonologi is advancing the platform through a staged development process that includes system refinement, clinical validation, regulatory preparation and future hospital deployment.

01

Wearable Ultrasound System Development

Foundation

02

Technical and Workflow Testing

Foundation

03

Evaluation in High-Acuity Clinical Settings

Evaluation

04

Expanded Clinical Validation

Expansion

05

Regulatory Development

Future

06

Initial Hospital Implementation

Future

RESEARCH-DRIVEN DEVELOPMENT

Building Clinical Evidence Carefully and Transparently

Current findings are preliminary and remain subject to continued technical testing, clinical validation and applicable regulatory review.

Additional information will be published as studies progress and results become available for public release.

Current Stage

Preliminary technical and clinical evaluation

Future Evidence

Expanded validation and public research materials

Regulatory Context

Subject to applicable regulatory review

RESEARCH & PUBLICATIONS

Read the Science Behind the Platform

Verified publications, conference materials, posters, white papers and technical reports will be added as they become available for public release.

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